Other Functions of Calcitriol

Calcitriol receptors have been identified in a variety of tissues in some of these, the effect of calcitriol is to induce the synthesis of calbindin-D in others, it is regulation of cell proliferation and differentiation. 

Calbindin-D9k has been identified in both the placenta and yolk sac of rats and mice, and increases in the later stages of gestation when there is considerable fetal uptake of calcium for mineralization of the skeleton. In both birds and mammals, calcitriol is also required for ovulation (Halloran, 1989). 

Calbindin-D28k is found in both the central and peripheral nervous systems. In the central nervous system, it is apparendy a constitutive, calcitriol-independent protein, whereas in peripheral nerves, it is induced by calcitriol. 

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