Other alkenylations, allylations, and arylations of imines

Vinylogous niitronate nucleophiles generated from / ,/ -disubstituted nitroolefins have been used for highly stereoselective aza-Henry reactions base catalysed by chiral 

The first example of olefinic C-H addition to iV-sulfonylaldimines and aryl aldehydes has been achieved through olefinic C-H bond activation by a rhodium complex. C-H bond functionalization by Rh(III) catalysts has also been used to achieve arylation of N-protected aryl aldimines by 2-arylpyridine and benzamide mechanistic studies have provided insight for further development of this means of creating a-branched amine functionality. A cobalt-A-heterocyclic carbene (NHC) catalyst has also directed arylation of aromatic aldimines through C-H bond functionalization of 2-arylpyridines.  

Hydrogenation of seven-membered cyclic imines of benzodiazepinones and benzodiazepines has been promoted by an Ir-diphosphine complex with up to 96% ee.  

Bifunctional rhenium complexes [Re(H)(N0)(PR3)(C5H40H)] (R = Cy, j-Pr) have effected the transfer hydrogenation of ketones and imines DFT calculations suggest a secondary-coordination-sphere mechanism for the former.  

An A-pivaloyl-L-prolineanilide promotes high-yield imine hydrosilylation by HSiCl3 with up to 93% ee. a-Deuterated amines have been formed with up to 99% ee by chi- Q ral phosphoric-acid-catalysed enantioselective transfer of deutaium from 2-deuterated benzothiazoline to ketimines the isotope effect suggests that C—D bond cleavage is rate determining. 0 

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