Other Aerobic Transformations and Degradation

Attention has been directed to the reactions catalyzed by cytochrome P450s that bring about important reactions leading to the loss of angular methyl groups at C-10 (with concomitant aromatiza-tion of ring A) and C-14, and the C-17 -COCHj side chain. These reactions are discussed further in Chapter 3, Part 1. The transformations of steroids and their precursor lanosterol have been extensively 

FIGURE 7.41 Demethylation of angular methyl groups (a) in steroids and related compounds, (b) in lanos-terol derivative and (c) summary of reactions for the formation of CHjO. 

---