Osteoporosis, treatment agents derivatives

Nylestriol is an estriol derivative (cyclopentylethinyles-triol), which has been tested in animals in combination with levonorgestrel as a potential agent for the treatment of post-menopausal osteoporosis. In a preliminary placebo-controlled study over 1 year using nylestriol 0.5 mg + levonorgestrel 0.15 mg once weekly in 119 patients, the combination produced no adverse effects on the uterus or breasts and there was no uterine bleeding... 

Their numerous derivatives have pronounced physiological activity. They include not only the extremely poisonous warfare agents such as sarin MeP(0)(0Pr )F, which is discussed in the next chapter, but also many compounds that have found use as in agriculture as insecticides, herbicides, chemical ripeners, etc., and important drugs, particularly in the treatment of osteoporosis, various viral infections and hypertension. 

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