Osteoblasts nanoceramics enhancing

Investigations of the underlying mechanism(s) revealed that the concentration, conformation, and bioactivity of vitronectin (a protein contained in serum that is known to mediate osteoblast adhesion ((Thomas et al., 1997) see the section Vitronectin ) was responsible for the select, enhanced adhesion (a crucial prerequisite for subsequent, anchorage-dependent-cell function) of osteoblasts on these novel nanoceramic formulations. Specifically, of the proteins (such as albumin, laminin, fibronectin, collagen, and vitronectin) tested, vitronectin adsorbed in the highest concentration on nanophase alumina after 4 hr moreover, competitive adsorption of vitronectin was 10% greater on nanophase compared to conventional alumina (Webster et al.,... 

It is imperative to determine properties of nanoceramics that enhance osteoblast and osteoclast functions Webster et al. (2000a,b, 2001 a,b) proposed the following ... 

Webster, T.J., Siegel, R.W, and Bizios, R., Nanoceramic surface roughness enhances osteoblast and osteoclast functions for improved orthopaedic/dental implant efficacy, Scr. Mater., 44,1639,2001. 

---