Glycosylation orthogonal

Scheme 4.17 Orthogonal glycosylations of thioglycosides and glycosyl fluorides.

The potential of the mannuronate ester donors in the formation of the p-mannosidic linkage has been demonstrated with the construction of a mannuronic acid alginate pentamer using a convergent orthogonal glycosylation.64... 

Fig. 6. Orthogonal glycosylation the glycosyl donor is attached to the solid support alternating coupling with a thioglycoside and a glycosyl fluoride acceptor.

An orthogonal glycosylation strategy was outlined in 1994 by Ogawa (21) that featured the use of two glycosyl donors... 

Kanie O, Ito Y, Ogawa T. Orthogonal glycosylation strategy in synthesis of extended blood group B determinant. Tetrahedron Lett. 1996 37 4551-4554. 

SCHEME 5.15 Synthesis of D-glucosamine oligomers by orthogonal glycosylation. 

The orthogonal glycosylation strategy was also employed in the synthesis of the blood group B determinant [30] and was applied to polymer-supported synthetic strategies [31]. 

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