Orthogonal Coupling Strategies

J.P. Tam, Y.A. Lu, Synthesis of large cyclic cystine-knot peptide by orthogonal coupling strategy using unprotected peptide precursor, Tetrahedron Lett. 1997, 38, 5599. 

The orthogonal coupling strategy can be applied to the synthesis of other polymeric compounds. Several approaches have been reported for construction of polymeric and dendritic structures on the basis of the orthogonal coupling strategy [29] (Figure 10). 

Figure 10. Some examples of the orthogonal coupling strategy in the synthesis of polymers and dendrimers.

Frechet involves the use of two different AB2 type monomers, this approach is called the orthogonal coupling strategy or two-step approach. 

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