Origin of Plasma Phosphatides

Strong additional evidence that plasma phosphatides, which in turn supply yolk phosphatides, are mainly derived from liver, is provided in investigations on formation of labeled phosphatides in the hepatectomized 

The observation that radiophosphatides are found in the kidney and small intestine of the hepatectomized dog leaves no doubt that the liver is not the only site of phosphatide formation in the animal body. The recoveries of phosphatide per gram kidney phosphatide or per gram small intestine phosphatide in the liverless dog do not differ significantly from those found in the intact dog, the specific activities of kidney and intestinal mucosa phosphorus being, after the lapse of five hours, 65 and 41%, respectively, of that of liver phosphatide phosphorus. 

Nevertheless, only negligible amounts of phosphatide were recovered from the plasma of the hepatectomized dog as late as 6 hours after excision of the liver, as is seen in Table XXVIII. For sake of comparison the figures obtained for labeled phosphatide content of plasma and tissues of normal dogs are stated in Table XXVII. 

Six hours after injection of labeled phosphate, the values for phosphatide P per gram tissue phosphatide were about 100 times greater in kidney 

Recovbbt of Intrapbritoneallt Injected as Phosphatide P in Plasma and Tissues of Normal Dogs (50) 

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