Transit time, mean organs

Relevant kinetic parameters (half-life, body pool, and mean transit time in organs) can be calculated. According to Equation 1 the specific activity in plasma shows a triphasic decay with half-lives of ti = 1.1 h, t2 == 22 h, and 3 == 61 h. The half-lives ti and 2 essentially describe the distribution of the compound into the system. The third half-life of 61 h (2.5 d) is valid for all tissues after attainment of the distribution equilibrium and represents the overall half-life of elimination from the body under the special conditions of the study (ascorbate status of the animals). 

The mean transit time (tmean) of C-radioactivity in organs has formally been evaluated using Equation 10 with XT as the C-radio-activity in the organs ... 

The resulting mean transit time may be used as a measure of the residence time of a molecule in an organ compared with a second organ, regardless of possible recirculation. 

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