Organozmc compounds

An organozmc compound that occupies a special niche m organic synthesis is lodo methyhinc iodide (ICH2ZnI) It is prepared by the reaction of zinc-copper couple [Zn(Cu) zinc that has had its surface activated with a little copper] with diiodomethane m diethyl ether... 

A wide vanety of nucleophiles, such as 1-alkylpyrroles, furans, thiophenls [51], phenols [52], anilmes [55, 54], indoles [55], CH-acidic compounds [56, 57], as well as organolithium [56], Gngnard [57, 59], organocadmiura, and organozmc compounds [56], undergo C-hydroxyalkylation with trifluoropynivates to yield derivatives of a-trifluoromethyi a-hydroxy acids. 

Table 10 Average bond lengths for some structurally characterized organozmc compounds containing a zinc-sulfur bond...

Organozmc reagents are not nearly as reactive toward aldehydes and ketones as Grig nard reagents and organolithium compounds but are intermediates m certain reactions of alkyl halides... 

A related fiinctionahzed organozmc reagent that has found use m the synthesis of biologically interesting compounds is the stable dialkoxyphosphmyldifluoromethylzinc reagent [93], which is readily prepared by direct reaction of bromo- or lododifluoromethyl-... 

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See also in sourсe #XX -- [ ]

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