Organometallic reagents Grignard

Reaction of Nitriles with Organometallic Reagents Grignard reagents add to a nitrile to give an intermediate imine anion that is hydrolyzed by addition of water to yield a ketone. 

Reaction of Acid Chlorides with Organometallic Reagents Grignard reagents react with acid chlorides to yield tertiary alcohols in which two of the substituents are the same. 

The reactions of carbohydrate derivatives with certain organometallic reagents (Grignard and Friedel-Crafts processes) have been reviewed in this Series and elsewhere.87 The attempted application of a Chugaev reaction to sugar xanthates was reported by Wolfram and Foster.88 It was found,... 

Addition of Nucleophiles Ll.6.1.3.1. Organometallic Reagents Grignard Reagents... 

Cyclopentylidene -1,4- dideoxy-1,4 -N- hydroxyimino- d, l- erythritol (a mejo-pyrrolidine described in Vol. 25, p. 206, ref. 44) can be readily converted into a nitrone with mercury(II) oxide and trapped in a selective manner with organometallic reagents (Grignards, alkyllithiums, etc.) to give the racemic N-hydroxypyrrolidines 32 (R = Me, Ph, PhCsC etc.). The compounds readily oxidize to aminoxyl free radicals. ... 

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