Organomanganese conjugate addition

COPPER-CATALYZED CONJUGATE ADDITION OF ORGANOMANGANESE CHLORIDES, RMnCI, to a,p-ETHYLENIC KETONES IN THF AT 0°C... 

Organomanganese reagents react with alkylidenemalonic esters or related compounds to give the conjugate addition products in good yields [33], They are very chemoselective, thus the conjugate addition product is exclusively obtained even in the presence of an ester or a ketone (Scheme 13.33). 

The Cu-catalyzed conjugate addition of organomanganese reagents to a,/3-ethyle-nic aldehydes gives similar results than those obtained via lithium organocuprates in the presence of trimethylchlorosilane (Scheme 13.41) [36]. However, the reaction is easier to carry out since the aldehyde is obtained in one step instead of the two steps required with an organocuprate. It is important since the partial aldoli-... 

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