Organomagnesium compounds, reaction symmetrization reactions

Similar acryloyl imidazolidinones have been used in the asymmetric 1,4-addition of organomagnesium compounds in the presence of a Lewis acid. The diastereoselectivity is variable and was found to be highly depending on the nature of all the reaction participants.227 A symmetric fumaramide, obtained from the camphor-derived Oppolzer sultam, adds Grignard reagents, yielding after hydrolysis monosubstituted succinic acids with up to 90% ee (Scheme 73).228... 

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