Organolithium-mediated diversification

Deng S, Taunton J (2005) Organolithium-mediated diversification of peptide thiazoles. Org Lett 7 299-301... 

Taunton and co-workers have reported a one-step racemization free organolithium-mediated diversification of peptide thiazoles. A mild procedure for the C5 lithiation of 2,4-disubstituted thiazoles has been described in this report, and an example is shown below. The method is compatible with A-Boc, A-trityl, carboxylic ester, and carboxamide protecting groups and has been used to functionalize directly the thiazole ring of cyclopeptide natural products. 

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