Organoclay wrapping

Hybrid Nanostructures Based on Organoclay Wrapping of Single Biomolecules 255... 

Higher-order organization of the organoclay-wrapped protein nanoparticles was achieved by tailoring the organic functionalities attached to the organoclay oligomers. 

The structural and functional integrity of organoclay-wrapped Mb and Hb molecules was demonstrated by retention of the secondary protein structure as well as distinctive shifts in the absorption spectra associated with oxygen or carbon monoxide binding to the heme metallocenter. The latter indicated that the wrapped... 

Fig. 8.14 TEM images showing (A) self-assembled layers of individual myoglobin molecules wrapped by condensed oligomers of AMP (B) top view of single sheet showing ordered superstructure of the hydrophobic organoclay wrapped myoglobin molecules.

Patil, A.J., Muthusamy, E. and Mann, S. (2004) Synthesis and self-assembly of organoclay-wrapped biomolecules. Angewandte Chemie-Intemational Edition, 43, 4928-4933. 

Fig. 8.18 Schematic diagram showing the potential scope of organically functionalized magnesium phyllosilicate (shown in top centre of figure) for the preparation of functional bioinorganic nanomaterials. (A) biomolecule-induced co-assembly of exfoliated aminopro-pyl-functionalized organoclay sheets to produce layered nanocomposites containing functional protein molecules (top left) or DNA (bottom left). (B) molecular wrapping...

Nanohybrids can be prepared in the form of intercalated layered nanocomposites produced by co-assembly of guest biomolecules in the presence of exfoliated organoclay sheets (Section 8.4), or by wrapping single biomolecules in ultrathin layers of condensed organoclay oligomers (Section 8.5). Such approaches should provide new general routes towards the development of functional biomaterials with numerous applications. 

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