Oregon margin

One reason for Roche s success with Dalmane was that it did not share two undesirable features of the barbiturates, the then reigning class of sedatives REM suppression and suicidal potency. The barbiturates are CNS depressants that can induce unconsciousness, but because they have a very low margin of safety they can also shut down the respiratory control system of the brain stem. That is how they kill, and that is why they are still popular in Oregon and other places where individuals are free to elect a definitive end to unbearably unpleasant conscious awareness. Physician-assisted suicide is sometimes accomplished by turning off breathing, by pulling the plug internally as it were. 

P8 Cascadia Margin off Oregon 73 m subbottom depth undefined area Westbrook et al. (1994)... 

Table XII shows some margins of safety calculated by Dr. Sheldon Wagner of Oregon State University, for a set of common prescription medicines. These include caffeine when prescribed at the dose level for which it is prescribed as a medicine, antibiotics, tranquilizers, vitamins, and other drugs. Notice that the margins of safety range from 1/2 through 100, 200, and up to 1000.

Friedman G.M. (1988) Methane-derived organogenic carbonates formed by subduction-induced pore-water expulsion along the Oregon/Washington margin Discussion and reply. Geol. Soc. Amer. Bull. 100, 622-623. 

Sample, J., and Reid, M.R., 1998, Contrasting hydro-geological regimes along strike-slip and thrust faults in the Oregon convergent margin Evidence from the chemistry of syntectonic carbonate cements and veins GSA Bulletin, 110 48-59. 

Torres, M.E., Wallmann, K., Trehu, A.M., Bohrmann, G, Borowski, W.S., and Tomaru, H., 2004. Gas hydrate growth, methane transport, and chloride enrichment at the southern summit of Hydrate Ridge, Cascadia margin off Oregon. Earth and Planetary Science Letters, 226 225-241. 

Wallace A. B. and Roper M. W. Geology and uranium deposits along the northeastern margin, McDermitt Caldera Complex, Oregon. Reference 16, 73-9. 

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