Optimizing Static Headspace Extraction Efficiency and Quantitation

Optimizing Static Headspace Extraction Efficiency and Quantitation 

There are many factors involved in optimizing static headspace extraction for extraction efficiency, sensitivity, quantitation, and reproducibility. These include vial and sample volume, temperature, pressure, and the form of the matrix itself, as described above. The appropriate choice of physical conditions may be both analyte and matrix dependent, and when there are multiple analytes, compromises may be necessary. 

The major factors that control headspace sensitivity are the analyte partition coefficient (K) and phase ratio (/ ). This was demonstrated by Ettre and Kolb [14]  

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