Optimize Pharmacological Profile of Oligopeptoids

Initial studies on short peptoid oligomers have revealed relatively poor pharmacokinetic properties [18, 79]. Despite the numerous advantageous attributes of peptoids in vitro, there are currently no peptoid-based therapeutics. However, a more thorough exploration of peptoid sequences may reveal species with more appropri- 

Efforts to investigate the questions posed here will lead to more useful peptoid designs while simultaneously leading to a better fundamental understanding of molecular recognition and sequence/structure/function relationships in non-natural, sequence-specific peptidomimetic ohgomers. 

and Barron, A.E. Mimicry of bioactive peptides by non-natural, sequence-specific peptidomimetic oligomers. Curr. Opin. Chem. Biol. 2002, 6, 872-877. 

Chiral N-substituted glycines can form stable helical conformations. Fold. Design 1997, 2, 369-375. 

and Zuckermann, R. N. Sequence-specific polypeptoids A diverse family of 

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