Optically pure 3,4-dihydroxybutyric acids

Several years ago, we introduced a method for the preparation of optically pure 3,4-dihydroxybutyric acids and their y-lactones based on the alkaline oxidation of 4-linked hexoses (2-4). 

Chiral 3-carbon synthons from optically pure 3,4-dihydroxybutyric acids. 

The general availability of optically pure 3,4-dihydroxybutyric acids has opened up several new routes to chiral 3-carbon fragments with a wealth of functionality. The (S)- and (R)-enantiomers of 3-amino-1,2-dihydroxypropane (15 and 19 respectively) are among the most useful chiral 3-carbon synthons. 

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See also in sourсe #XX -- [ ]

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