Optic nerve hypoplasia

I. Rodemer, C., Thai, T.R, Brugger, B., Kaercher, T., Werner, H., Nave, K.A., Wieland, F., Gorgas, K., Just, W.W. 2003. Inactivation of ether lipid biosynthesis causes male infertility, defects in eye development and optic nerve hypoplasia in mice. Hum. Mol. Genet. 12 1881-1895. 

Quinine crosses the placenta and can be found in relatively high concentrations in cord blood it is also excreted in the breast milk. Data about possible teratogenicity related to the therapeutic use of malaria are scanty (SEDA-14, 239). Hypoplasia of the optic nerve and deafness have been reliably described in children born after failure to induce abortion with the drug. 

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