Opioids toxidromes

Opioid toxidrome effects include miosis, respiratory depression, and CNS depression. More serious... 

Acute toxicity induced by pentazocine is primarily associated with central nervous system (CNS) effects that include dizziness, anxiety, hallucinations, mood alterations, and seizures. Respiratory depression, increased PaCOi levels, pulmonary edema, and apnea may occur. Tachycardia, increased systolic and diastolic blood pressure, pinpoint pupils, nausea, vomiting, and abdominal pain have also been reported. In a recently published case series, 40% of acute pentazocine overdose patients did not have the classic opioid toxidrome of CNS and respiratory depression with miosis. 

Toxic syndromes ( toxidromes ) are clinical syndromes that are essential for the successful recognition of poisoning patterns. A toxidrome is the constellation of clinical signs and symptoms that suggests a specific class of poisoning. The most important toxidromes are (1) anticholinergic, (2) cholinergic, (3) opioid and opioid withdrawal, (4) sedative-hypnotic and sedative-hypnotic withdrawal, and (5) sympathomimetic. Symptoms for these toxidromes are listed in Table 34-2. 

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