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Opioid tripeptide 5-antagonist

In summary, [Dmtr] deltorphin B possesses remarkable agonist activity and exerts effects on both g- and 8-opioid receptors in vitro and in vivo, and also that the newly discovered opioid tripeptide antagonist, DTA, exerts antagonist activity primarily toward the 8- opioid receptor, in keeping with in vitro data. [Pg.805]

Tire rationale in designing peptides with the substitution of methyl groups at the 2 and 6 position of Tyr (Dint) Dmt-Tic-OH (DTOH) and Dmt-Tic-Ala-OH (DTAOH), was to minimize the message domain of opioid peptides while maintaining activity. Thus, a class of highly potent and selective opioid di- and tripeptide 5 antagonist [72] were synthesized... [Pg.808]


See other pages where Opioid tripeptide 5-antagonist is mentioned: [Pg.817]    [Pg.818]    [Pg.448]    [Pg.200]    [Pg.113]    [Pg.425]   
See also in sourсe #XX -- [ Pg.30 , Pg.808 ]




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