One Pot Multi-reagent Combinations

In 1974 Rebek published the first example of the simultaneous apphcation of two immobilized systems. This pioneering mechanistic study exploited the site isolation properties of polymers for an examination of the existence and movement of short-hved solution species between two insoluble polymeric trapping agents suspended in a common solution (Fig. 2.4). It was demonstrated that a polymer 

Two years later in 1977 the Cohen group stimulated the next major development by the introduction of the simultaneous use of two antagonistic supported reagents which they named the wolf and lamb approach [38]. This allowed two immobilized systems to be used in conjunction with one another to achieve one-pot reaction sequences that were not possible by employing their homogeneous 

In the same year an efficient one-pot oxidation and reduction sequence was also described for the cleavage of 1,2-diols to their corresponding primary alcohols [42]. This process was an excellent demonstration of two immobilized incompati- 

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So far only we have scratched the surface of what might be possible with polymer-bound reagents in multi-step organic synthesis. We believe it is possible to use these reagents in many elaborate one-pot multi-reagent combinations, even with the aim of discovering new chemical reactions. 

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