One-Pot CuAAC Reactions for Ligand Synthesis

In the previously discussed click methodologies, the azide and aUcyne reactants were S3mthesized and isolated before their use in the CuAAC reaction. In an effort to further improve the synthetic efficiency and safety of the CuAAC reaction, a number of groups have developed one-pot CuAAC methodologies in which either the alkyne or azide reactant is generated in situ and reacted immediately without isolation and purification. 

It is clear that the CuAAC click reaction can be exploited to rapidly synthesize families of functionalized ligand architectures, and this synthetic versatility could lead to many potential applications. However, before the full potential of these click ligands can be realized, an understanding of the coordination properties of 1,4-disubstituted-l,2,3-triazoles is required. In the following sections, we will examine the coordination properties of monodentate, bidentate, tridentate, and polydentate ligands containing 1,4-disubstituted-l,2,3-triazole units. 

3 Monodentate and Bridging Coordination Modes in 1,4-Disubstituted-1,2,3-Triazole Ligands 

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