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Oncogenic mutation, causes

Some established cell lines were derived from malignant tissue. Many of these cell lines can form tumors when injected into susceptible animals. Other established cell lines are not Uunorigenic. However, exposure to carcinogens, and irradiation can cause these cells to form tumors in susceptible animals. In addition, transformation can be caused by spontaneous mutations, by growth factors, and by viral (or oncogenic) transformation (Table 6). Malignant transformation is defined as consisting of the series of events that cause normal cells to develop the capacity to form tumors. [Pg.477]

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See also in sourсe #XX -- [ Pg.421 ]



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Causes of Oncogenic Mutations

Mutation causes

Mutations caused

Oncogenes

Oncogenic

Oncogenic mutation

Oncogens

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