Oligopeptides recognition

Biomimetic syntheses of isodithyrosine natural products, and an approach to chemistry and molecular recognition of secoaglucovancomycin and related oligopeptides 97YGK1029. 

Mrksich, M., M.E. Parks, and P.B. Dervan. Hairpin peptide motif A new class of oligopeptides for sequence-specific recognition in the minor-groove of double-helical DNA. J. Am. Chem. Soc. 1994, 116, 7983-7988. 

As mentioned above, some naturally occurring cyclic hosts that possess molecular recognition capabilities were known before crown ethers (the first artificial host molecules) were discovered. For example, the cyclic oligopeptide valinomycin and the cyclic oligosaccharide cyclodextrin were found to bind to specific guest molecules. The chemical modification of cyclodextrin was particularly well-researched, and artificially modified cyclodextrins became one of the most important compoimds used in host-guest chemistry. 

Several authors have compared imprinted polymers to biological receptors and even the term plastic antibodies has been coined to describe these remarkable materials. To a large extent, this comparison rests on a spectacular work of Mosbach and co-workers [24], who showed that theophylline- and diazepam-imprinted polymers displayed a specificity rather similar to that of polyclonal antibodies in binding studies with the template and its close structural analogues. However, it is the recognition of nucleotide or oligopeptide sequences which is... 

Active transport mechanisms for the intestinal absorption of amino acids, oligopeptides, monosaccharides, monocarboxylic acids, phosphate, bile acids, and a number of vitamins have been identified and the review by Tsuji and Tamai provides an excellent summary of those mechanisms. The potential use of intestinal peptide and hepatic bile acid carriers to enhance drug absorption also has been reviewed. Structural and molecular modeling studies have postulated molecular structural features necessary for substrate recognition by the intestinal peptide carrier and the bile acid carrier. ... 

Scheme 1-23 Equilibria between members of the three sets of conjugates of types A, B, and C each with p-RNA moieties (gray) to make self-assembly possible and oligopeptide moieties (green) to allow molecular recognition.

Alternatively, a recognition site in close proximity to the ATP-binding site can be targeted with an oligopeptide as the reporter ligand, whose sequence is derived from the activating kinase MKK3b in case of p38 MAP kinase [82], The inhibition of the protein-protein interaction with a small peptide could serve as a template for peptidomimetic inhibitor development [83, 84],... 

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