Oligopeptides biological activities

Larger oligopeptide hormones are also stabilized by such interactions. A nuclear magnetic resonance spectroscopic study of somatostatin by Hirschmann and co-workers (Arison et al., 1981) revealed that the side chains of phenylalanine-6 and phenylalanine-11 make the edge-to-face aromatic-aromatic interaction. Synthetic studies have shown that elimination of one or both of the aromatic groups at positions 6 and 11 abolishes biological activity. However, there is one notable exception. When... 

The methodology to compute the three-dimensional structures of oligopeptides should be extendable to larger molecules, that is, proteins. Besides the intrinsic interest in oligopeptides as important biologically active molecules, that is why so much effort is devoted to these small molecules, namely, for an... 

As described above, ion channels play an important role in biological activity and they can be mimicked using a supramolecular approach. In this area of research, stable pore structures are formed from artificial molecules that are buried in a lipid bilayer membrane. For example, artificial channel structures have been prepared using specifically designed oligopeptides. 

Naturally occurring oligopeptides with more than one biological activities M. LIAKOPOULOU-KYRIAKIDES... 

NATURALLY OCCURRING OLIGOPEPTIDES WITH MORE THAN ONE BIOLOGICAL ACTIVITIES... 

Davis CM and Vincent JB (1997b) Isolation and characterization of a biologically active chromium oligopeptide from bovine liver. Arch Biochem Bio-phys 339 335-343. 

Over the past decade, the unique activity of oligopeptides, known as protein transduction domains (PTDs) or cell penetrating peptides (CPPs), has made it possible to transduce biologically active macromolecules into living cells [2, 3]. It was accomplished by conjugating a PTD to the desired macromolecule. Various kinds of macromolecules have been successfully internalized into living... 

A group of cyclic oligopeptide antibiotics (C. A to Z) discovered in 1972 from lower fungi (e.g., Tricho-derma polysporum) with remarkable biological activ-... 

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