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Oligopeptide polymer conjugates

A General Model for the Hierarchical Self-Organization of Oligopeptide-Polymer Conjugates 89... [Pg.89]

Jahnke, E., Severin, N., Kreutzkamp, P. et al. (2008) Molecular level control over hierarchical structure formation and polymerization of oligopeptide-polymer conjugates. Advanced Materials, 20,409 14. [Pg.90]

Self-Assembly of P-Sheet Forming Oligopeptides and Their Polymer Conjugates... [Pg.80]

Fig. 3 A tumor-targeted polymer-drug conjugate. The major elements include (i) a polymeric drug-carrier that is water-soluble, bicompatible or biodegradable, non-immunogenic (ii) targeting moieties (iii) a linker between a drug and the carrier. The linker can be a) a chemical bond such as ester or amide. An ester bond is more stable at lysosomal pH than at plasma pH (7.4) while an amide bond is stable at both lysosomal and plasma pH b) an oligopeptide linker that is degradable by specific enzymatic hydrolysis and c) an acid labile linker that is degradable at lysosomal pH but stable at plasma pH. Fig. 3 A tumor-targeted polymer-drug conjugate. The major elements include (i) a polymeric drug-carrier that is water-soluble, bicompatible or biodegradable, non-immunogenic (ii) targeting moieties (iii) a linker between a drug and the carrier. The linker can be a) a chemical bond such as ester or amide. An ester bond is more stable at lysosomal pH than at plasma pH (7.4) while an amide bond is stable at both lysosomal and plasma pH b) an oligopeptide linker that is degradable by specific enzymatic hydrolysis and c) an acid labile linker that is degradable at lysosomal pH but stable at plasma pH.
Abstract Hyphenation of electrospray ionization witii ion-trap multistage mass spectrometry (ESI-MS°) provides charactoisation of subtle molecular structure of both syntiietic and natural aliphatic polyesters as well as oligomeric products of their biodegradation. Implementation of multisti e MS technique for structural studies of the novel bio-inspired polymers including poly[(R,S)-3-hydroxybutyrate], a-PHB, telechelics and a-PHB conjugates with oligopeptides has been demonstrated. The novel results concerned with evaluation of the subtle structure of macroinitiators obtained by partial depolymerisation of selected natural poly(3-hydroxyalkanoate)s, PHA, are also presented. [Pg.341]

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See also in sourсe #XX -- [ Pg.78 , Pg.89 ]



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Hierarchical oligopeptide-polymer conjugate

Oligopeptide

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