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Oligonucleotides in MALDI

Due to their numerous acidic hydrogens, oligonucleotides require desalting prior to MALDI analysis, e.g. by using cation exchange resins (Chap. 10.4.2). [24] [Pg.429]

Similar procedures are necessary when other ionization methods are applied to this compound class. [Pg.430]


Chou, C.-W. Williams, P Limbach, P. A. Matrix influence on the formation of positively charged oligonucleotides in MALDI MS. Int. J. Mass Spectrom. 1999, 193, 15-27. [Pg.181]


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