Olanzapine Warfarin

To date, the combined olanzapine-warfarin regimen has not revealed any pharmacokinetic interactions. No interactions have been reported to date between aripiprazole and... 

Naproxen Olanzapine Tacrine Tertiary TCAs Theophylline Warfarin Type 1C antiarrhythmics Codeine Erythromycin Estrogen Quinidine Phosphodiesterase-5 inhibitors Protease inhibitors TCAs Terfenadine Zolpidem... 

Drugs that may be affected by SSRIs Drugs that may be affected by SSRIs include alcohol, benzodiazepines, beta blockers, buspirone, carbamazepine, cisapride, clozapine, cyclosporine, diltiazem, digoxin, haloperidol, hydantoins, lithium, methadone, mexiletine, nonsedating antihistamines, NSAIDs, olanzapine, phenothiazines, phenytoin, pimozide, procyclidine, ritonavir, ropivacaine, sumatriptan, sulfonylureas, sympathomimetics, tacrine, theophylline, tolbutamide, tricyclic antidepressants, and warfarin. 

Pharmacokinetic and pharmacodynamic profiles of olanzapine have been extensively reviewed (266). Olanzapine does not inhibit CYP isozymes, and no clinically significant metabolic interactions were found of olanzapine with aminophylline, biperiden, diazepam, ethanol, fluoxetine, imipramine, lithium, or R/S-warfarin. 

Maya JF, Callaghan JT, Bergstrom RF, Cerimele BJ, Kassahun K, Nyhart EH, Brater DC. Olanzapine and warfarin drug interaction. ClmPhcumacol Ther 99T)6 182. 

A single dose of olanzapine did not alter the pharmacokinetics or anticoagulant effect of a single dose of warfarin. 

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