Of rutro compounds

A. number of rutro compounds used m ndturdl product synthesis have been prepared by the n of alkyl halides Some recent examples are summarized m Table 2 4 fi-Nitro carbonyl compounds are important for synthesis of natural products The reaction of alkyl vinyl ketones with sodium nitrite and acetic acid in THF gives thecorrespondmgfi-nitro carbonyl compounds in42-82% ""rhis method is better for the preparation of fi-nitro carbonyl compounds than the nitration of the corresponclmg halides... 

Double Michael addiQoas of rutro compounds beanng tethered acidic carbons to 3-butyn-3-one under NaH catalysis give nitrocyclohexanes v/ith high stereoselectivity The products are transformed into rrruii -fused bicyclic compounds via the Dickmarm reaction on treatment with base fEq 4 139 ... 

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