Octitols anhydro

The evolution of an asymmetric synthesis of the differentially 2,6-anhydro-octitol ring of the altohyrtins has been described. An intramolecular epoxide ring opening was the key step in the synthesis, the epoxide itself being obtained via substrate-controlled epoxidation of the corresponding alkene (Scheme 5 see also Chapter 2). ... 

Acetamido-3,7-anhydro-2-azi- 1,2,4-trideoxy-D-g/ycero-D-gu/o-octitol (69) was synthesized from the glycosyl nitrile (68) (Scheme 11) as a potential photo affinity reagent... 

Condensation of D-ribose 5-phosphate with dihydroxy acetone phosphate under the influence of rabbit muscle aldolase gives D-gfycero-D-aftro-octulose which exists mainly in the pyranose ring form, and on treatment with triethylsilane is reduced to the C-glycoside 116, that is, a 2,6-anhydro-octitol. ... 

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