Ochrosia moorei

Recently three new derivatives of 18,19-dihydrocorynantheol (21) have been isolated from natural sources. 10-Hydroxydihydrocorynantheol (22) has been found in Ochrosia moorei F. Muell. (26), and its structure has been determined by chemical analysis and by IR, H-NMR, and mass spectra. Ochropposinine (23) was isolated first in 1972 from Ochrosia oppositifolia K. Schum. (27, 28) and recently from Ochrosia moorei (26) by Potier s group. The relative configuration of C-20 as well as the absolute configuration of 23 have been elucidated. Ochromianine (24) isolated from Ochrosia miana H.Bn. ex Guill. (29) could be described very probably as 1 l-methoxycorynan-17-ol. The relative configuration of C-20 has not as yet been determined exactly. 

Ahond et al. recently reported the isolation of two epimeric /V-oxides of 10-methoxydihydrocorynantheol from the trunk bark of Ochrosia moorei (26). The absolute configuration of the stereo centers at the annellation of rings C and D are 35,4/ in 26 and 35,45 in 27. 

Ellipticine is the major alkaloid of the trunk bark of Ochrosia moorei F. von Muell., in which it occurs in association with 27 other alkaloids, including 10-methoxyellipticine, ellipticine 7Vb-oxide, and 3,14-dihydroellipticine.43rf A point of chemotaxonomic interest is that the genera Ochrosia and Neisosperma can be distinguished on the basis of their ellipticine/10-methoxyellipticine content one or both of these alkaloids are present in Ochrosia species, but absent from Neisosperma species. 

Ochrosia glomerata Valeton Ochrosia moorei F. Muell. 

---