Occurrence and structure of primitive bile acids in lower vertebrates

Most primitive bile acids found in lower vertebrates possess the carbon skeleton of cholesterol. Differences within these C27 bile acids are associated with number, position, and configuration of hydroxyl groups and with side-chain unsaturation. In addition, some C2g bile acids have been found in bile of a few species of amphibians. Cholenoic acid derivatives have not been found in lower vertebrates. A list of primitive bile acids in lower vertebrates is given in Table 2. 

Systematic name of primitive bile acid (trivial name) 

24-Tetrahydroxy-24-methyl-5/S-cholestan-26-oicacid 3 ,7o,12a-Trihydroxy-24-methyl-5/8-cholestan-26-oic acid 3a,7a,12o-Trihydroxy-5tt-cholest-22-ene-24-carboxylicacid 3 ,7a,l 2 -Trihydroxy-5 -cholest-22-ene-24-carboxylic acid 2 8,3 ,7a,12a-Tetrahydroxy-5/8-cholestan-26-oic acid (arapaimic acid) 

22-Tetrahydroxy-5j8 holestan-26-oic acid 3a,7o,12a,24-Tetrahydroxy-5 -cholestan-26-oicacid (24/J,25S)-3a,7a,12a,24-Tetrahydroxy-5 -cholestan-26-oic acid (varanic acid) 

26-Tetrahydroxy-5o-cholestan-27-oic acid 3a,7a,12a,26-Tetrahydroxy-5/8-cholestan-27-oic acid 3a,7a,12a-Trihydroxy-5a-cholestan-26-oic acid 

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Ill) Occurrence and structure of primitive bile acids in lower vertebrates... 

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