Obsessive-compulsive disorder serotonin hypothesis

Barr, L.C., Goodman, W.K., Price, L. H., McDougle, C.J. and Char-ney, D.S. (1992) The serotonin hypothesis of obsessive compulsive disorder implications of pharmacologic challenge studies. / Clin Psychiatry 53(4, Suppl) 17-28. 

Barr LC, Goodman WK, Price LH, et al The serotonin hypothesis of OCD implications of pharmacologic challenge studies. J Chn Psychiatry 4 17-28s, 1992 Barr LC, Goodman WK, Price LH The serotonin hypothesis of obsessive compulsive disorder. Int Clin Psychopharmacol 8 (suppl 2 79-82, 1993 Barr LC, Goodman WK, McDougle CJ, et al Tryptophan depletion in patients with OCD who respond to serotonin reuptake inhibitors. Arch Gen Psychiatry 51 309-17, 1994... 

Goodman WK, McDougle CJ, Price LH, et al Beyond the serotonin hypothesis a role for dopamine in some forms of obsessive compulsive disorder J Clin Psychiatry 51 (suppl) 36-43, 1990a... 

Antidepressants cover a wide range of indications and include depression, obsessive-compulsive disorders, anxiety, pain, panic, eating disorders or social phobia. The monoamine hypothesis of depression is an often-used term that describes a concept that arose over 50 years ago when a direct link was observed between major depression and imbalance/deficiency of available monoamines such as serotonin and catecholamines. 

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