O-Thymol

SYNS 2-p-CYMENOL FEMANo. 2245 2-HYDROXY-p-CYMENE ISOPROPYL-o-CRESOL 5-ISOPROPYL-2-METHYLPHENOL ISOTHYMOL 2-METHYL-5-ISOPROPYLPHENOL o-THYMOL... 

Synonyms CAS 499 75-2 2-P-CYMENOL ISOPROPYL-O-CRESOL 5-IS0PR0PYL-2-METHYLPHEN0L ISOTHYMOL 2-METHYL-5-ISOPROPYLPHENOL O-THYMOL... 

Synonyms 2-p-Cymenol Cymophenol 2-Hydroxy-p-cymene Isopropyl-o-cresol 5-lsopropyl-2-methylphenol Isothymol 2-Methyl-5-isopropylphenol 2-Methyl-5-(1-methylethyl) phenol o-Thymol Empirical C10H14O... 

Tne oil thus tnvited vea a cooameruiivl peld of 00 3 per ceut. of thymol of a perf<.-ct)y white crystslliue character. Carvacrol it also probably reseut in the oil, as well as cymene, and traces o d-HmonenP.. 

Thymol, Cj Hj O, is the principal constituent of the oils of thyme and ajotvan seeds. It is isopropyl-mefa-cresol of the constitution—... 

If thymol be treated with sodium and a current of carbonic acid be passed through it, o-thymotic acid is formed, which when liberated by means of hydrochloric acid and purified by distillation, melts at 123°. Thymotic acid has the constitution—... 

Carvacrol, Cj Hj O, is a phenol isomeric with thymol, with which it is frequently found associated, especially in certain types of thyme and origanum oils. 

However, for m-cresol purple, thymol blue and o-nitroaniline, many estimated K, values yielded straight lines with eqn. 4.77, so that with these indicators the spectrophotometric method failed. This result led Bos to check some of the above results by means of the potentiometric method of Tanaka and Nakagawa64 applied to titrations in glacial acetic acid also he obtained the following data ... 

Tertiary and aromatic nitroso compounds are not readily accessible consequently not many reductions have been tried. Nitrosobenzene was converted to azobenzene by lithium aluminum hydride (yield 69%) [592], and o-nitrosobiphenyl to carbazole, probably via a hydroxylamino intermediate, by treatment with triphenylphosphine or triethyl phosphite (yields 69% and 76%, respectively) [298]. Nitrosothymol was transformed to amino-thymol with ammonium sulfide (yield 73-80%) [245], and a-nitroso-/J-naphthol to a-amino-/J-naphthol with sodium hydrosulfite (yield 66-74%) [255]. 

Color pH toot Nmler o Sthytenodicmiru Dipkeniflamina Thymol... 

Similarly with the raising of the b.p. in violet or reddish-violet soln. of iodine in benzophenone, carbon disulphide, ethyl chloride, chloroform, carbon tetrachloride, ethylene chloride or benzene or in brown soln. of ethyl alcohol, methyl alcohol, thymol, ethyl ether, methylal, or acetone. The values for the last three solvents were rather low, presumably because of the chemical action of solute on solvent. High values with benzene are attributed to the formation of a solid soln. of solvent and solid. Confirmatory results were found by J. Hertz with naphthalene, and by E. Beckmann and P. Wantig with pyridine. The results by I. von Ostromisslensky (o-nitrotoluene), by G. Kriiss and E. Thiele (glacial acetic acid), and by H. Gautier and G. Charpy indicate polymerization, but they are not considered to be reliable. 

Aeschbach, R., Loliger, J., Scott, B.C., Murcia, A., Butler, J., Halliwell, B. and Aruoma, O.l. (1 994) Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol. Food and Chemical Toxicology 32(1), 31-36. 

Cresol Red-Thymol Blue TS, 851 Cresol Red TS, 851 o-Cresolsulfonphthalein, 860 p-Cresyl Acetate, 474, 568, 684, (S 1)66 p-Cresyl Isobutyrate, 558 p-Cresyl Methyl Ether, 524 Criteria for Food Chemicals Codex Grade, xx... 

Determination of Acidity or Alkalinity of NG. Place a lOg sample of the MG by pipet into a tared beaker and retare. Add lOOml of benzene and transfer to a 250-ml separatory funnel when dissolved. Wash twice with 50-ml portions of neutral discd w, combining the washes in a 230 inl beaker. Add several drops of bromo-thymol blue indicator and immediately titrate with O.OlN NaOH if yellow, or with 0.01 N sulfuric acid if blue. Run a blank on lOQml of benzene and cnirect the first citration value. Then, % acidity (as sulfuric acid) or alkalinity (as sodium carbonate) = kVN/W, where k is... 

B.S. Green and co-workers developed an improved preparation of the clathrate host compound tri-o-thymotide (TOT) and other trisalicylide derivatives. The synthesis began with the preparation of orfho-thymotic acid from thymol using the Kolbe-Schmitt reaction. The authors found that the yield of the product was dramatically increased when the reactants, solvents, and reagents were dried before use. Thus, thymol was dissolved in dry xylene, sodium metal was added and the temperature was kept at 130 °C for 20h in a dry carbon dioxide atmosphere. The desired carboxylated product was isolated in good yield. Finally, cyclodehydration with POCI3 afforded TOT in almost quantitative yield. 

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