O-Phthaloyl dichloride

Compounds with enato 1,3-diaza chelate rings, e.g., (138) (cf. (37) and (38)), are oxidized to radical species which form 6,6 -C—C (139), and 6,6 -C=C linked bismacrocycles, which can be reduced to form 6,6 -biscyclams (140) (Scheme 33).177 [Ni(cyclam)]2+ and [Fe(cyclam)(MeCN)2]3+ are aerially oxidized to the 6-6 -ethylidene linked cations (141) which reduce to the 6,6 -biscyclam cations. Reaction of (138) with bifunctional o-phthaloyl dichloride gave bisacyl-linked macrocycles (142).178... 

C-sodium acetate is produced by the reaction of the Grignard reagent, methylmagnesium bromide in diethyl ether, with cyclotron-produced nC-carbon dioxide at -15°C (Oberdorfer et al, 1996). After reaction, the product is allowed to react with O-phthaloyl dichloride to produce nC-acetyl chloride, which is then hydrolyzed to 11C-acetate with saline. The solution is filtered through a 0.22-pm membrane filter. 11C-acetate has been found to be stable at pH between 4.5 and 8.5 for up to 2 h at room temperature. The overall yield is about 10-50%. It is used for the measurement of oxygen consumption (oxidative metabolism) in the heart, since acetyl CoA synthetase converts 11C-acetate to acetyl coenzyme A after myocardial uptake, which is metabolized to 11C-C02 in the tricarboxylic acid cycle. 

The peroxide can be obtained in 55% yield by reaction of o-phthaloyl dichloride with sodium peroxide. ... 

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