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O6-methylguanine

Alkylating agents can alter certain bases of DNA For example, the highly reactive chemical dimethylsul-fate (Fig. 8—35b) can methylate a guanine to yield O6-methylguanine, which cannot base-pair with cytosine. [Pg.295]

Eoff, R.L., Irimia, A., Egli, M., and Guengerich, F.P. (2007) Sulfolobus solfataricus DNA polymerase Dpo4is partially inhibited by wobble pairing between O6-methylguanine and cytosine, but accurate bypass is preferred. J. Biol. Chem., 282,1456-1467. [Pg.327]

Woodside, A.M. and Guengerich, F.P. (2002) Misincorporation and stalling at O6-methylguanine and 06-benzylgua-nine evidence for inactive polymerase complexes. Biochemistry, 41, 1039-1050. [Pg.327]

Gaffney, B.L. and Jones, R.A. (1989) Thermodynamic comparison of the base pairs formed by the carcinogenic lesion O6-methylguanine with reference both to Watson-Crick pairs and to mismatched pairs. Biochemistry, 28, 5881-5889. [Pg.327]

See other pages where O6-methylguanine is mentioned: [Pg.280]    [Pg.975]    [Pg.498]    [Pg.167]    [Pg.478]    [Pg.327]    [Pg.327]    [Pg.280]    [Pg.975]    [Pg.498]    [Pg.167]    [Pg.478]    [Pg.327]    [Pg.327]    [Pg.276]    [Pg.80]   
See also in sourсe #XX -- [ Pg.311 , Pg.412 ]



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