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Nucleus Hexokinase

FIGURE 15-17 Regulation of hexokinase IV (glucokinase) by sequestration in the nucleus. The protein inhibitor of... [Pg.578]

Fig. 4. Dimerization and phosphorylation of Hxk2. Hexokinase PII (Hxk2) was one of the first proteins to be implicated in glucose repression and adaptation to fermentative metabolism. However, its role is still unclear. Hxk2 is a phosphoprotein which exists in a mono- or dimeric state. Only the monomer is phosphorylated. Hxk2 is found in the cytoplasm and the nucleus which suggests that it may play roles in both hexose metabolism and transcriptional regulation [76,77]... Fig. 4. Dimerization and phosphorylation of Hxk2. Hexokinase PII (Hxk2) was one of the first proteins to be implicated in glucose repression and adaptation to fermentative metabolism. However, its role is still unclear. Hxk2 is a phosphoprotein which exists in a mono- or dimeric state. Only the monomer is phosphorylated. Hxk2 is found in the cytoplasm and the nucleus which suggests that it may play roles in both hexose metabolism and transcriptional regulation [76,77]...
FIGURE 15-17 Regulation of hexokinase IV (glucokinase) by sequestration in the nucleus. The protein inhibitor of hexokinase IV is a nuclear binding protein that draws hexokinase IV into the nucleus when the fructose 5-Ophosphate concentration in liver is high and releases it to the cytosol when the glucose concentration is high. [Pg.578]

Hexokinase IV (glucokinase) is sequestered in the nucleus of the hepatocyte, but is released when the cytosolic glucose concentration rises. [Pg.583]

See other pages where Nucleus Hexokinase is mentioned: [Pg.369]    [Pg.578]    [Pg.578]    [Pg.97]    [Pg.54]    [Pg.54]    [Pg.206]    [Pg.578]    [Pg.80]    [Pg.245]   
See also in sourсe #XX -- [ Pg.180 ]



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