Nucleotides sugar functionality

Further functionalization at OH-2 was also explored [187]. From monosacchari-dic (ot-gluco, 129) and disaccharidic (a-malto, 143) CMGLs, several types of bisfunctionalized systems were synthesized by reaction with allylamine or propar-gylamine. For example, compound 155 was prepared and used in a synthesis of the nucleotide sugar analog 156 (Scheme 38). In the context of studies on the... 

Fig. 8.—Pathway of Biosynthesis of Some Sugar Nucleotides That Function as Gly-cosyl Donors for Biosynthesis of Glycoproteins and Glycoenzymes. (The heavy arrows indicate the sites of feedback control of the reactions.135)...

Nucleotides are monomers that link together to form polymers called nucleic acids deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). Each nucleotide comprises a C5 sugar, a phosphate group, and a nitrogen base. Nucleotides are major constituents of the hereditary material and can act as energy currency (ATP) in cells. Some derivatives of nucleotides can function in oxidation-reduction reactions in the cell. 

As indicated in Fig. 8A, in addition to the reactions originating with glucose, alternative pathways exist for the formation of several of the nucleotide sugars directly from their monosaccharide constituents. These reactions may be used for the conversion of dietary monosaccharides, and the contribution by these pathways to the nucleotide sugar pool will be a function largely of the composition of the diet. The utilization of fucose for synthesis of GDP-fucose by this route is catalyzed by fucose kinase and GDP-fucose pyrophosphorylase ... 

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