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Nucleotide triphosphate, intracellular levels

Hudarabine phosphate is a fluorinated nucleotide analog of the antiviral agent vidarabine. Its cytotoxicity is not well understood. It is rapidly dephospho-rylated at the cell membrane level and then rephos-phorylated intracellularly by deoxycytidine kinase to the active triphosphate derivative. It inhibits DNA polymerase and DNA primase. It is also incorporated into DNA and RNA. Hudarabine is administered intravenously by infusion over 30-120 min. It is eliminated by renal excretion with a terminal half life 10 hours. Adverse effects include myelosuppres-sion, nausea, vomiting, chills and fever. The number of CD4 positive cells is reduced and the incidence of opportunistic infections is increased. [Pg.453]

See other pages where Nucleotide triphosphate, intracellular levels is mentioned: [Pg.462]    [Pg.291]    [Pg.142]    [Pg.586]    [Pg.215]    [Pg.15]    [Pg.1193]    [Pg.204]    [Pg.198]    [Pg.109]    [Pg.50]    [Pg.579]    [Pg.198]    [Pg.579]    [Pg.176]    [Pg.6724]    [Pg.67]    [Pg.269]    [Pg.1]    [Pg.852]    [Pg.265]   
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