Nucleotide-serotonin complex

Table III further illustrates an observation which was made in previous studies with nucleotides and tryptamine or serotonine (Wagner and Lawaczeck 1972 Lawaczeck and Wagner 1974). Apparent affinity constants obtained from the chemical shift of non-equivalent protons revealed considerable variations which were beyond the experimental error. We proposed an explanation for this (Lawaczeck and Wagner 1974) by assuming conqilexes of minor probability with different stereochemistry and/or stoichiometry. The results in Table III Indicate variation in the apparent affinity constants only with the nucleosides. Apparently complex formation of tryptamine with the bases is more homogeneous than with the nucleosides.

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