Nucleotide excision repair resynthesis

Fig. 1. Schematic illustration of nucleotide excision repair in prokaryotes and eukaryotes. The basic steps are conserved damage recognition and dual incisions to excise DNA damage, helicase activity to displace excised oligomer and repair factors, and resynthesis/ligation to restore the integrity of the DNA molecule. (See Color Insert.)...

Excision repair involving removal of nucleotides in the neighborhood of DNA damage followed by resynthesis and rejoining of the DNA. Evidence of this form of repair is used in some screening tests. 

DNA damage is now known to affect every aspect of the cellular metabolism and to include extensive modifications in transcriptional regulation, as well as life-or-death decisions. Simple DNA lesions can be repaired by excision of damaged nucleotides and resynthesis of the missing segments of the molecule by using the intact strand as template. 

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