Nucleosome entry/exit point

Fig. 4. Possible mechanism for HMGB proteins in facilitating the unwrapping of nucleosomal DNA. The model postulates that the binding of an HMGB protein at an exit/entry point for the wrapped DNA increases the accessibility of the wrapped DNA both at the exit/entry points adjacent to the bound HMGB protein and also at internal positions. Such a conformational change would facilitate the binding both of sequence-specific regulatory proteins and of remodeling complexes. Adapted from Ref. [119] with permission.

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