Nucleophilic substitution in pyridazines

The second most important nucleophilic substitution in pyridazine A-oxides is the replacement of a nitro group. Nitro groups at the 3-, 4-, 5- and 6-position are easily substituted thermally with a chlorine or bromine atom, using acetyl chloride or hydrobromic acid respectively. Phosphorus oxychloride and benzoyl chloride are used less frequently for this purpose. Nitro groups in nitropyridazine A-oxides are easily replaced by alkoxide. The... 

Much of the recently reported work on nucleophilic substitution at C-3 and C-4 of pyrimido[4,5-f]pyridazine-5,7-diones is included in a review of nucleophilic substitution in pyridazines <2001CHE1461>. 6,8-... 

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See also in sourсe #XX -- [ , ]

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