Nucleophiles in Sn2 substitutions

Organomagnesium and organolithium compounds are strongly basic and nucleophilic. Despite their potential to react as nucleophiles in SN2 substitution reactions, this reaction is of limited utility in synthesis. One limitation on alkylation reactions is competition from electron transfer processes, which can lead to radical reactions. Methyl and other primary iodides usually give the best results in alkylation reactions. 

Carbohydrate imidazolylsulfonates (imidazylates) [36] are a type of sulfonic add ester that deserves special comment because these compounds react readily with nucleophiles in SN2 substitution processes. Although imidazylates are not used as frequently as inflates in substitution reactions, they appear to be comparable in reactivity [Eq. (16) 37,38],... 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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