Nucleobase skeletons

Several conductive CT solids with nucleobase skeletons have been developed in the TTF systems having uracil moieties (crt = 10 -2 S cm ) [123-127]. Also several attempts have been undertaken to investigate the CT complexes in a variety of biochemical systems, especially using nucleobases (Scheme 9) [18, 104]. Estimation of 7p of the nucleobases, as potential components in CT complexes, indicate that they are reasonably effective Tt-donors particularly in the case of guanine (G) 7d = 7.64—7.85 eV vs adenine (A, 7.80-8.26 eV), cytosine (C, 8.45-8.74 eV), and thymine (T, 8.74-8.87 eV) [128-131]. 

Adsorption is the simplest method of immobilization as it does not involve the formation of covalent bond formation between the ODN and the surface (see Fig. 7.1b). Instead, it relies on electrostatic interactions between negatively charged sugar-phosphate skeleton of DNA and positively charged electrode surface and/or interactions involving the nucleobases and the surface. Physical adsorption is often achieved on electrochemical oxidized carbon electrodes [11-14] (HOPGE, GCE, CPE) and less often on gold [15] or ITO [16] surfaces. For examples, cationic polymers, such as chitosan, have... 

Double-headed nucleoside with a hemiacetal linker between the C2 and the C4 -positions, with two uracil nucleobases organized on a bicyclic skeleton has been synthesized for the first time by Nielsen and co-workers. With the aid of /hh it has been found that the new compound is conformationally restricted and is locked in an N-type conformation. 

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