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Nucleic acid with cystamine

Modification of Nucleic Acids and Oligonucleotides with Cystamine... [Pg.87]

More recently, a series of linear PAAs with repetitive disulfide linkages in their backbone (SS-PAAs) has been developed as biodegradable carriers for gene delivery. These bioreducible SS-PAA polymers were synthesized via Michael-type polyaddition of the primary amine monomers to Nff -cystamine-bisactylamide (CBA) in equimolar monomeric ratios. These polymers have been designed to form nanocomplexes with nucleic acids, which remain relatively stable in extracellular media but are prone to fast degradation in the reductive intracellular environment due to cleavage of the... [Pg.367]

See other pages where Nucleic acid with cystamine is mentioned: [Pg.84]    [Pg.92]    [Pg.72]   
See also in sourсe #XX -- [ Pg.87 ]



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Cystamine

Nucleic Acids and Oligonucleotides with Cystamine

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