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Nucleic acid bases photoreactions

PHOTOSTABILITY AND PHOTOREACTIVITY IN BIOMOLECULES QUANTUM CHEMISTRY OF NUCLEIC ACID BASE MONOMERS AND DIMERS... [Pg.435]

An interesting and significant outcome is the finding that the pyrimidine bases of nucleic acids (uracil, thymine, and cytosine) are photoreactive and undergo [2 + 2] cycloadditions on irradiation with ultraviolet light. Thymine, for example, gives a dimer of structure 7 ... [Pg.1394]

As an illustration of bimolecular reactions, the formation of pyrimidine nucleobase adducts in the excited state will be presented here (see Roca-Sanjudn et al. 2008b Serrano-P6rez et al. 2008d). Among the possible photoreactions that pyrimidine (Pyr) bases of nucleic acids may undergo upon ultraviolet (UV) irradiation, cyclobutane thymine dimers (ToT or CBT) formed by intrastrand adjacent thymine bases (see O Fig. 14-26) constitute one of the major photoinduced lesions, particularly in cellular DNA, in spite of the direct reparation by a light-activated mechanism (DNA photolyase) in which abnormal bonds are cleaved. Unrepaired or... [Pg.546]

See other pages where Nucleic acid bases photoreactions is mentioned: [Pg.63]    [Pg.1272]    [Pg.1296]    [Pg.2]    [Pg.371]    [Pg.409]    [Pg.266]    [Pg.46]    [Pg.359]    [Pg.383]    [Pg.338]    [Pg.362]    [Pg.20]    [Pg.669]    [Pg.108]    [Pg.311]    [Pg.548]    [Pg.159]   
See also in sourсe #XX -- [ Pg.1296 ]



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