Nuclear magnetic resonance metabolomics applications

The identification of changes in the metabolome can help characterize the biochemical functions of enzymes in the proteome [5, 24]. Not all metabolic changes, however, provide easy readouts. Therefore, more sophisticated analytical methods have been developed to detect and quantify changes in metabolome. The application of modem analytical tools, such as nuclear magnetic resonance (NMR) [19] and mass spectrometry (MS) [5, 24], are the primary tools of metabolomics researchers. In particular, MS has found increased usage as mass spectrometers have improved their sensitivity and mass resolution. 

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